The SIG P250 can be chambered in .22 Long Rifle .380 ACP, 9×19mm Parabellum, .357 SIG, .40 S&W, and .45 ACP.
The P250 pistol is a short recoil operated, locked breech pistol. It uses the SIG Sauer locking system in which an enlargement of the chamber locks into the ejection port on the slide.
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